Over the past two decades, many teams around the world demonstrated very interesting applications of non equilibrium cold atmospheric plasmas in the domains of sterilization and decontamination. Recently, researchers have shown these kinds of plasmas are of great interest in medicine (control of bleeding, dermatology, wound healing, chronic infected wound healing, skin diseases). Our very recent work demonstrated that non equilibrium cold plasmas at atmospheric pressure are also clearly very promising for the treatment of certain types of tumors. In Orleans, an important project, PLASMED, dedicated to the study of therapeutic applications of plasmas in oncology, gather together plasma researchers, biologists, medical doctors and partners from companies. Three essential tasks are performed within the frame of this project concerning: the development and characterization of cold atmospheric plasma sources, especially FE-DBD and Plasma Gun; in vitro evaluation of cold atmospheric plasma action on different cancer cell lines; in vivo trials with main targets such as lung, pancreas and colorectal cancers. Already important results have been obtained in vitro and especially in vivo showing for the first time an antitumor activity of non thermal plasma. In vitro assessments on two human cancer cell lines (glioblastoma U87MG and colorectal carcinoma HCT-116) showed that cold atmospheric plasmas generated a large amount of ROS, leading to the formation of DNA damages. This resulted in a multi-phase cell cycle arrest and a subsequent apoptosis induction. In vivo experiments on U87MG bearing mice showed that FE-DBD plasma induced a reduction of bioluminescence (that closely follows tumors activity) and tumor volume as compared to non-treated mice. After proving the antitumor activity of the Plasma Gun (that allow production of plasmas at long distances (tens of cm to m)) in vitro on the different cell lines already mentioned and MIA PaCa (carcinoma pancreatic cell line), efforts are presently done to demonstrate its efficacy for endoscopic treatments in rather complex or difficult to reach organs such as lungs and pancreas. All the different points mentioned above will be presented in the talk together with the last result concerning the characterization of the Pulsed Atmospheric Plasma Streams, PAPS, produced by the Plasma Gun system The authors gratefully acknowledge the Conseil Regional du Centre, Germitec, CNRS and CG45 for their support.