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Article Dans Une Revue Tetrahedron: Asymmetry Année : 2009

Attrition-enhanced preferential crystallization combined with racemization leading to redissolution of the antipode nuclei

Résumé

Preferential crystallization is an effective and cheap resolution method which is limited by the nucleation of the antipode, even in the case of in situ racemization. Grinding (during an in situ racemization experiment) was done to promote the crystals stemming from the seeds by enhancing the dissolution step of smaller ones (resulting from nucleation). Thus, the solid remains of a single chirality even if the supersaturation exceeds the Ostwald limit of the antipode.

Domaines

Chimie organique

Dates et versions

hal-01147124 , version 1 (29-04-2015)

Identifiants

Citer

Guillaume Levilain, Céline Rougeot, F. Guillen, Jean-Christophe Plaquevent, Gérard Coquerel. Attrition-enhanced preferential crystallization combined with racemization leading to redissolution of the antipode nuclei. Tetrahedron: Asymmetry, 2009, 20 (24), pp.2769. ⟨10.1016/j.tetasy.2009.11.015⟩. ⟨hal-01147124⟩
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