Enantiomerically pure 1,2,5-triphenylphospholane through the synthesis and resolution of the chiral trans-(2,5)-diphenylphospholanic acid
Résumé
The synthesis and resolution of trans-(2,5)-diphenylphospholanic acid 7 is described. The phosphinic acid 7 was converted into optically active (1,2,5)-triphenylphospholane 5 which was used as a chiral ligand in Rh-catalyzed hydrogenation of N-acetyl dehydrophenylalanine methyl ester to give quantitative yield of methyl N-acetylwphenylalaninate with 82 % e.e.