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Article Dans Une Revue International Journal of Hydrogen Energy Année : 2010

Maturation of [FeFe]-hydrogenases: Structures and mechanisms

Résumé

Maturation of [FeFe]-hydrogenases, consisting in the synthesis and assembly of a di-iron center with a dithiolate bridging ligand as well as CO and CN ligands, depends on the concerted action of three metalloproteins, HydE, HydF and HydG. HydE and HydG are “Radical-SAM” enzymes involved in the synthesis of the ligands. HydF is proposed to function as a scaffold protein in which the di-iron center is assembled before being transferred to the hydrogenase. Here we review the current knowledge regarding the structure of the three maturases and the mechanisms of synthesis and assembly of the di-iron center of [FeFe]-hydrogenases.

Dates et versions

hal-01145486 , version 1 (24-04-2015)

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Yvain Nicolet, Juan-Carlos Fontecilla-Camps, Marc Fontecave. Maturation of [FeFe]-hydrogenases: Structures and mechanisms. International Journal of Hydrogen Energy, 2010, 35 (19), pp.10750-10760. ⟨10.1016/j.ijhydene.2010.02.056⟩. ⟨hal-01145486⟩
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