Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: from structure to reactivity - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Dalton Transactions Année : 2014

Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: from structure to reactivity

Résumé

An NMR study of a 1 : 1 mixture of a chiral lithium amide (4a) and n-BuLi shows that depending on the solvent employed (Et2O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselective alkylation of o-tolualdehyde by these same species.

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Chimie
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Dates et versions

hal-01144757 , version 1 (22-04-2015)

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Gabriella Barozzino-Consiglio, Mathieu Rouen, Hassan Oulyadi, Anne Harrison-Marchand, Jacques Maddaluno. Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: from structure to reactivity. Dalton Transactions, 2014, 43 (38), pp.14219-14228. ⟨10.1039/C4DT01156B⟩. ⟨hal-01144757⟩
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