A detailed numerical simulation of a radiation fog event with a single column model is presented, which takes into account recent developments in microphysical parametrizations. One-dimensional simulations are performed using the computational fluid dynamics model Code_Saturne and the results are compared to a very detailed in situ dataset collected during the ParisFog campaign, which took place near Paris, France, during the winter 2006–2007. Special attention is given to the detailed and complete diurnal simulations and to the role of microphysics in the fog life cycle. The comparison between the simulated and the observed visibility, in the single-column model case study, shows that the evolution of radiation fog is correctly simulated. Sensitivity simulations show that fog development and dissipation are sensitive to the droplet-size distribution through sedimentation/deposition processes but the aerosol number concentration in the coarse mode has a low impact on the time of fog formation.