Enterprises are complex live organisms of humans and networked machines including diverse types of computational devices. Enterprise interoperability promotes the interaction between companies based in the interoperability between such companies and between devices and services inside the company. Knowledge management is another important aspect that is extensively observed in the dynamic enterprise ecosystem. It is understandable that studies make different types of assessment for machines and people. In this sense we can ask on the interest of studying humans along machines in the chain of collaboration inside the Enterprise Interoperability Ecosystem. What we propose is to establish measures that promote interoperability between computational devices and humans, at the same time that we can promote interoperability between humans using computational devices to interact between each other.