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Poster De Conférence Biochemical Society Transactions Année : 2014

Female puberty acceleration by male odour in mice: neural pathway and behavioural consequences

Résumé

In female mice, exposure to male chemosignals results in early puberty onset characterized by advanced vaginal opening and higher uterine weight. Evidence suggests that the male chemosignals responsible for acceleration of female puberty are androgen-dependent, but not all of the compounds that contribute to puberty acceleration have been identified. The male chemosignals are primarily detected and processed by the vomeronasal system including the vomeronasal organ, the accessory olfactory bulb and the medial amygdala. By contrast, the mechanism by which this olfactory information is integrated in the hypothalamus is poorly understood. In this context, the recent identification of the neuropeptide kisspeptin as a gatekeeper of puberty onset may provide a good candidate neuropeptide system for the transmission of chemosensory information to the gonadotrope axis.

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Autre [q-bio.OT]
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Dates et versions

hal-01130522 , version 1 (11-03-2015)

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Mélanie Jouhanneau, Laura A. Szymanski, Matthieu Keller. Female puberty acceleration by male odour in mice: neural pathway and behavioural consequences. Meeting of the Behaviour Meets Biochemistry: Animal Making Sense of Molecules Making Scents, Feb 2014, Londres, United Kingdom. Portland Press, Biochemical Society Transactions, 42 (4), 2014, Biochemical Society Transactions. ⟨10.1042/BST20140048⟩. ⟨hal-01130522⟩
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