The additional N-glycosylation site of the equine LH/CG receptor is not responsible for the limited cyclic AMP pathway activation by equine chorionic gonadotropin relative to luteinizing hormone - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Reproductive biology Année : 2011

The additional N-glycosylation site of the equine LH/CG receptor is not responsible for the limited cyclic AMP pathway activation by equine chorionic gonadotropin relative to luteinizing hormone

Résumé

In order to investigate the role of the unique seventh N23-glycosylation site of the equine LH/CG receptor (eLHCGR) in the cAMP pathway activation, COS-7 cells were transiently transfected with either the wild-type or the mutant eLHCGRN23Q cDNA and challenged with porcine LH and eCG for cAMP production. We showed that the N23-glycosylation site of the eLHCGR is not required for the functional coupling of the receptor with the cAMP pathway and is not responsible for the limited potency of eCG relative to pLH to activate this receptor.
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hal-01129548 , version 1 (10-03-2015)

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Marie Saint-Dizier, Florence Foulon-Gauze, François Lecompte, Yves Combarnous, Maryse Chopineau. The additional N-glycosylation site of the equine LH/CG receptor is not responsible for the limited cyclic AMP pathway activation by equine chorionic gonadotropin relative to luteinizing hormone. Reproductive biology, 2011, 11 (2), pp.157-164. ⟨10.1016/S1642-431X(12)60052-7⟩. ⟨hal-01129548⟩
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