Left Ventricular Pressure-Volume Analysis : an example of function assessment on a sheep
Résumé
Simultaneous pressure and volume measurements allow extraction of valuable parameters for left ventricle function assessment. MRI has proven to be the most accurate method for volume estimation, nonetheless measuring pressure during MRI acquisitions remains a challenge given the magnetic nature of the widely used pressure transducers. In this study we show the feasibility of simultaneous in vivo pressure-volume acquisitions with MRI using optical pressure sensors. Pressure-volume loops are calculated while inducing three inotropic states in a sheep and functional indexes are extracted to characterize systolic and diastolic performance. Functional indexes evolved as expected in response to positive inotropic stimuli. The end-systolic elastance, representing the contractily index, the diastolic mycocardium compliance, and the cardiac work efficiency all increased when inducing inotropic state enhancement. The association of MRI and optical pressure sensors successfully allowed pressure-volume loop analysis and functional left ventricle evaluation.
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