Sustainable Food Security and Sustainable Diets are widely acknowledged and studied by the international community. The links between food regimes of populations and the environmental and socioeconomic issues concerning individuals, countries and geographical areas, are nowadays recognized and proved. Nevertheless, identifying metrics for a multidimensional analysis remains a challenging task. This methodological paper proposes a revisited vulnerability approach for an innovative application to food security and sustainability issues in the agrofood system. The aim is to identify qualitative and quantitative methods to consider the interrelating factors leading to vulnerability, in order to inform decision-making and adaptive strategies. An original methodological framework of the integrated vulnerability approach to analyze food insecurity and unsustainability is presented together with a metric methodology.