La radiothérapie induit-elle une agressivité accrue des cellules tumorales du glioblastome ? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Bulletin du Cancer Année : 2014

La radiothérapie induit-elle une agressivité accrue des cellules tumorales du glioblastome ?

Résumé

Glioblastoma multiform is the most common and aggressive brain tumor with a worse prognostic. Ionizing radiation is a cornerstone in the treatment of glioblastome with chemo-radiation association being the actual standard. As a paradoxal effect, it has been suggested that radiotherapy could have a deleterious effect on local recurrence of cancer. In vivo studies have studied the effect of radiotherapy on biological modification and pathogenous effect of cancer cells. It seems that ionizing radiations with photon could activate oncogenic pathways in glioblastoma cell lines. We realized a review of the literature of photon-enhanced effect on invasion and migration of glioblastoma cells by radiotherapy.

Domaines

Cancer
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Dates et versions

hal-01120707 , version 1 (26-02-2015)

Identifiants

Citer

A. Falk, C. Moncharmont, M. Guilbert, J.-B. Guy, G. Alphonse, et al.. La radiothérapie induit-elle une agressivité accrue des cellules tumorales du glioblastome ?. Bulletin du Cancer, 2014, 101 (9), pp.876-880. ⟨10.1684/bdc.2014.1946⟩. ⟨hal-01120707⟩
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