This paper discusses results of an integrated land use and transport modelling, carried out for the territory of the French region of North-Pas-de-Calais using the software Tranus. The interest of this research was to simulate, test and evaluate impacts of a Transit Oriented Development regional plan, using the LUTI modelling tool. Therefore were analyzed evolution of transport demand modal share and dynamics of real estate market and of localization choices of population and activities. TOD is a model of urban development that promotes high quality, mixed and multi-functional densification, located in proximity of transit nodes and corridors, with priority to non-motorized mobility and with the aim to reduce land consumption and car dependency. Multiple TOD examples can be found at urban and metropolitan scale, with different characteristics depending on the socio-economic and territorial contexts, while rarer are interventions at a regional scale. Therefore this research aim to analyze the application of a TOD regional plan, applied to a specific group of regional railway nodes and corridors, selected for their TOD potential. Results showed that some rail corridors initially selected, clearly confirmed their TOD potential and that TOD effects are more evident in areas with good basic levels of attractiveness and of economic dynamism. Furthermore, if policy of densification clearly contributes to concentrate residential demand in urban zones and to limit urban sprawl, further incentives has to be organized in favor of transit use. More interesting effects are in fact found by simulating transit integrated tariff policies between regional train and bus services, as well as interventions discouraging car use, in addiction to TOD urban configurations.