Intra-tracheal administration of Gd-based nanoparticles: an effective approach for MRI detection and follow-up of lung tumor
Résumé
Lung cancer is the leading cause of cancer deaths worldwide. The burden of this disease could be greatly reduced with an early diagnostics, which often results in a positive prognosis. In this context, MRI can play a major role being a noninvasive imaging technique, characterized by good soft tissue contrast, high spatial resolution, and absence of ionizing radiation. We present here an in vivo MRI longitudinal study of lung cancer detection in tumor-bearing immunodeficient mice through intratracheally- and intravenously- administered multimodal Ultra-Small Rigid Platforms (USRPs) [1] and a commercially available Gd-based contrast agent. The localization of the tumor was validated against bioluminescent imaging (BLI) and histology.