Small rigid platforms functionalization with quaternary ammonium: Targeting extracellular matrix of chondrosarcoma - Archive ouverte HAL Access content directly
Journal Articles Nanomedicine: Nanotechnology, Biology and Medicine Year : 2014

Small rigid platforms functionalization with quaternary ammonium: Targeting extracellular matrix of chondrosarcoma

Jessica Morlieras
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Abstract

This work takes place in the “cartilage targeting strategy”, consisting in using the quaternary ammonium (QA) function as a vector to proteoglycans (PGs) of extracellular matrix (ECM). The objective was to demonstrate that QA could address gadolinium based small rigid platforms (SRP) to PG-rich tumors. SRP were functionalized with QA, radiolabeled with 111Indium and evaluated for biodistribution in vivo, respectively to non functionalized SRP, in two experimental models: (i) the HEMCSS human xenograft model; (ii) the Swarm rat chondrosarcoma (SRC) orthotopic model. The contribution of cellular uptake to tumoral accumulation of nano-objects was also determined from in vitro binding. In the SRC model expressing a highly and homogeneously distributed PG content, tumor accumulation and retention of SRP@QA were increased by 40% as compared to non-functionalized SRP. When considering the radiosensitizing potential of gadolinium based SRP, these results provide hopes for the radiobiological approach of highly resistant tumor such as chondrosarcoma.

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Cancer
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Dates and versions

hal-01115673 , version 1 (11-02-2015)

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Elisabeth Miot-Noirault, Aurélien Vidal, Jessica Morlieras, Pauline Bonazza, Philippe Auzeloux, et al.. Small rigid platforms functionalization with quaternary ammonium: Targeting extracellular matrix of chondrosarcoma. Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10 (8), pp.1887-1895. ⟨10.1016/j.nano.2014.06.011⟩. ⟨hal-01115673⟩
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