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Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2015

Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes

Résumé

The molecular recognition of human telomeric G-quadruplexes by a novel cationic π-extended NiII-porphyrin (NiII-TImidP4) is studied in aqueous solutions via (chir)optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting assay, and computational molecular modeling. The results are systematically compared with the recognition by a conventional meso-substituted NiII-porphyrin (NiII-TMPyP4), which allows us to pinpoint the differences in binding modes depending on the G-quadruplex topology. Importantly, FRET melting assays show the higher selectivity of NiII-TImidP4 towards human telomeric G4 than that of NiII-TMPyP4.
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Dates et versions

hal-01115274 , version 1 (11-04-2024)

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Jenifer Rubio Magneto, Florent Di Meo, Mamadou Lo, Cécile Delcourt, Sébastien Clément, et al.. Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes. Organic & Biomolecular Chemistry, 2015, 13 (8), pp.2453-2463. ⟨10.1039/c4ob02097a⟩. ⟨hal-01115274⟩
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