tmle.npvi: targeted, integrative search of associations between DNA copy number and gene expression, accounting for DNA methylation: Fig. 1.
Résumé
We describe the implementation of the method introduced by Chambaz et al. (2012). We also demonstrate its genome-wide application to the integrative search of new regions with strong association between DNA copy number and gene expression accounting for DNA methylation in breast cancers. Availability and implementation: An open-source R package tmle.npvi is available from CRAN (http://cran.r-project.org/). Contact: pierre.neuvial@genopole.cnrs.fr
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