Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study. - Archive ouverte HAL
Journal Articles Bone Marrow Transplantation Year : 2015

Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study.

1 EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée
2 Labex_Transplantex - Labex_Transplantex
3 Hématologie -Immunologie -Cibles thérapeutiques
4 Etablissement français du sang- Rhône-Alpes [Lyon]
5 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
6 EFS - Etablissement français du sang [Besançon]
7 EFS - Etablissement français du sang [Poitiers]
8 Laboratoire de Biologie Médicale [Rennes]
9 EFS - Etablissement français du sang - Auvergne-Rhône-Alpes
10 ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé
11 CTS AQUITAINE-LIMOUSIN - Centre de Transfusion Sanguine Aquitaine-Limousin
12 LABM - Laboratoire d'Analyses de Biologie Médicale
13 EFS - Etablissement français du sang [Clermont-Ferrand]
14 Développement du Systeme Immunitaire
15 Etablissement français du sang [Angers]
16 GIMAP - Groupe Immunité des Muqueuses et Agents Pathogènes
17 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
18 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
19 Laboratoire de Génétique Moléculaire et d'Histocompatibilité [Brest]
20 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
21 EFS - Etablissement français du sang [Nice]
22 Immunologie cellulaire et tissulaire
23 Etablissement français du sang [Rouen]
24 Etablissement français du sang [Caen]
25 Service Immunologie Biologique [Paris]
26 Hôpital Necker - Enfants Malades [AP-HP]
27 RFGM - Registre France Greffe de Moelle [Saint-Denis La Plaine]
28 Service d'hématologie [Hôpital Edouard Herriot - HCL]
29 Service greffe de moelle osseuse
30 Etablissement Français du Sang [Nantes]
31 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
Ioannis Theodorou
Ibrahim Yakoub-Agha

Abstract

We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.Bone Marrow Transplantation advance online publication, 3 November 2014; doi:10.1038/bmt.2014.253.

Keywords

Dates and versions

hal-01095283 , version 1 (15-12-2014)

Identifiers

Cite

Katia Gagne, Pascal Loiseau, Valérie Dubois, P. Perrier, Anne Dormoy, et al.. Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study.. Bone Marrow Transplantation, 2015, 50, pp.232-236. ⟨10.1038/bmt.2014.253⟩. ⟨hal-01095283⟩
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