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Article Dans Une Revue Macromolecular Bioscience Année : 2014

A Novel Crosslinked Hyaluronic Acid Nanogel for Drug Delivery

Silvia Santos Pedrosa
  • Fonction : Auteur
Catarina Goncalves
  • Fonction : Auteur
Laurent David
Miguel Gama
  • Fonction : Auteur

Résumé

An amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 +/- 0.4 nm (n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker-1,4-Bis(3-[2-pyridyldithio]propionamido)-butane (DPDPB). The drug loading efficiency of the reticulated and non-reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin. Results suggest that crosslinked nanogel exhibit higher stability upon dilution and drug loading efficiency and proves to be a redox sensitive material. The nanogels hold great potential as stealth carriers of lipophilic drugs.

Dates et versions

hal-01094014 , version 1 (11-12-2014)

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Citer

Silvia Santos Pedrosa, Catarina Goncalves, Laurent David, Miguel Gama. A Novel Crosslinked Hyaluronic Acid Nanogel for Drug Delivery. Macromolecular Bioscience, 2014, 14, pp.1556-1568. ⟨10.1002/mabi.201400135⟩. ⟨hal-01094014⟩
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