Biodegradable Ethylene-Bis(Propyl)Disulfide-Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In-Vitro Drug Delivery. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Advanced Materials Année : 2014

Biodegradable Ethylene-Bis(Propyl)Disulfide-Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In-Vitro Drug Delivery.

Résumé

Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.

Domaines

Chimie organique

Dates et versions

hal-01093856 , version 1 (11-12-2014)

Identifiants

Citer

Jonas Croissant, Xavier Cattoën, Michel Wong Chi Man, Audrey Gallud, Laurence Raehm, et al.. Biodegradable Ethylene-Bis(Propyl)Disulfide-Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In-Vitro Drug Delivery.. Advanced Materials, 2014, 26 (35), pp.6174-6180. ⟨10.1002/adma.201401931⟩. ⟨hal-01093856⟩
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