Identifying distant homologous viral sequences in metagenomes using protein structure information - Archive ouverte HAL
Conference Papers Year : 2014

Identifying distant homologous viral sequences in metagenomes using protein structure information

Abstract

It is estimated that marine viruses daily kill about 20% of the ocean biomass. Identifying them in water samples is thus a biological issue of great importance. The metagenomic approach for virus identication is a challenging task since their sequences carry a lot of mutations making them hardly possible to find by standard homology searches. The PEPS VAG project aims at establishing a novel methodology that uses structures of proteins as extra-information in order to annotate metagenomes without relying on homology of sequences. In the context of the first experiments made on the metagenome of station 23 of the TARA Ocean Project, we use the structures of capsid protein to infer the sequence signature of their fold, in order to find them in the metagenome. We present here the methodology, the first experiments and the on-going improvements.
Fichier principal
Vignette du fichier
VAG_ECCB14.pdf (32.18 Ko) Télécharger le fichier
Origin Files produced by the author(s)
Loading...

Dates and versions

hal-01090987 , version 1 (05-12-2014)

Identifiers

  • HAL Id : hal-01090987 , version 1

Cite

Martine Boccara, Mathilde Carpentier, Jacques Chomilier, François Coste, Clovis Galiez, et al.. Identifying distant homologous viral sequences in metagenomes using protein structure information. ECCB'14 Workshop on Recent Computational Advances in Metagenomics, Sep 2014, Strasbourg, France. ⟨hal-01090987⟩
675 View
217 Download

Share

More