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Journal Articles Nature Communications Year : 2014

Lymphocytes can self-steer passively with wind vane uropods

Abstract

A wide variety of cells migrate directionally in response to chemical or mechanical cues, however the mechanisms involved in cue detection and translation into directed movement are debatable. Here, we investigate a model of lymphocyte migration on the inner surface of blood vessels. Cells orient their migration against fluid flow, suggesting the existence of an adaptive mechano-tranduction mechanism. We find that flow detection may not require molecular mechano-sensors of shear stress and detection of flow direction can be achieved by the orientation in the flow of the non-adherent cell rear, the uropod. Uropods act as microscopic wind vanes that can transmit detection of flow direction into cell steering via the on-going machinery of polarity maintenance, without need for novel internal guidance signalling triggered by flow. Contrary to chemotaxis, which implies active regulation of cue-dependant signalling, upstream flow mechanotaxis of lymphocytes may only rely on a passive self-steering mechanism.
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Dates and versions

hal-01086070 , version 1 (24-11-2014)

Identifiers

Cite

Marie-Pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C Lellouch, Francois Gallet, et al.. Lymphocytes can self-steer passively with wind vane uropods. Nature Communications, 2014, 5, pp.5213. ⟨10.1038/ncomms6213⟩. ⟨hal-01086070⟩
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