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Article Dans Une Revue Current Opinion in Structural Biology Année : 2013

Coarse-grain modelling of protein-protein interactions.

Résumé

Here, we review recent advances towards the modelling of protein-protein interactions (PPI) at the coarse-grained (CG) level, a technique that is now widely used to understand protein affinity, aggregation and self-assembly behaviour. PPI models of soluble proteins and membrane proteins are separately described, but we note the parallel development that is present in both research fields with three important themes: firstly, combining CG modelling with knowledge-based approaches to predict and refine protein-protein complexes; secondly, using physics-based CG models for de novo prediction of protein-protein complexes; and thirdly modelling of large scale protein aggregates.

Dates et versions

hal-01084639 , version 1 (19-11-2014)

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Marc Baaden, Siewert J Marrink. Coarse-grain modelling of protein-protein interactions.. Current Opinion in Structural Biology, 2013, 23 (6), pp.878-86. ⟨10.1016/j.sbi.2013.09.004⟩. ⟨hal-01084639⟩
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