High-Throughput Screening of Metal-N-Heterocyclic Carbene Complexes against Biofilm Formation by Pathogenic Bacteria. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ChemMedChem Année : 2014

High-Throughput Screening of Metal-N-Heterocyclic Carbene Complexes against Biofilm Formation by Pathogenic Bacteria.

Résumé

A set of molecules including a majority of metal-N-heterocyclic carbene (NHC) complexes (metal=Ag, Cu, and Au) and azolium salts were evaluated by high-throughput screening of their activity against biofilm formation associated with pathogenic bacteria. The anti-planktonic effects were compared in parallel. Representative biofilm-forming strains of various genera were selected (Listeria, Pseudomonas, Staphylococcus, and Escherichia). All the compounds were tested at 1 mg L−1 by using the BioFilm Ring Test. An information score (IS, sum of the activities) and an activity score (AS, difference between anti-biofilm and anti-planktonic activity) were determined from normalized experimental values to classify the most active molecules against the panel of bacterial strains. With this method we identified lipophilic AgI and CuI complexes possessing aromatic groups on the NHC ligand as the most efficient at inhibiting biofilm formation.

Domaines

Chimie

Dates et versions

hal-01081349 , version 1 (07-11-2014)

Identifiants

Citer

Thierry Bernardi, Stéphanie Badel, Pascal Mayer, Jérome Groelly, Pierre De frémont, et al.. High-Throughput Screening of Metal-N-Heterocyclic Carbene Complexes against Biofilm Formation by Pathogenic Bacteria.. ChemMedChem, 2014, 9, pp.1140-1144. ⟨10.1002/cmdc.201402012⟩. ⟨hal-01081349⟩
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