Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Experimental Medicine Année : 2006

Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity

Résumé

Colitis involves immune cell–mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1 is an epithelial ectoenzyme with a pantetheinase activity that provides cysteamine/cystamine to tissue. Using the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-colitis model we show here that Vanin-1 deficiency protects from colitis. This protection is reversible by administration of cystamine or bisphenol A diglycidyl ether, a peroxisome proliferator-activated receptor (PPAR) 후 antagonist. We further demonstrate that Vanin-1, by antagonizing PPAR 후, licenses the production of inflammatory mediators by intestinal epithelial cells. We propose that Vanin-1 is an epithelial sensor of stress that exerts a dominant control over innate immune responses in tissue. Thus, the Vanin-1/ pantetheinase activity might be a new target for therapeutic intervention in infl ammatory bowel disease.
Fichier non déposé

Dates et versions

hal-01076821 , version 1 (23-10-2014)

Identifiants

Citer

Carole Berruyer, Laurent Pouyet, Virginie Millet, M. Martin Florent, Aude Legoffic, et al.. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity. Journal of Experimental Medicine, 2006, 203 (13), pp.2817-2827. ⟨10.1084/jem/20061640⟩. ⟨hal-01076821⟩
229 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More