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Journal Articles Nucleus Year : 2014

Microtubules move the nucleus to quiescence.

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Abstract

The nucleus is a cellular compartment that hosts several macro-molecular machines displaying a highly complex spatial organization. This tight architectural orchestration determines not only DNA replication and repair but also regulates gene expression. In budding yeast microtubules play a key role in structuring the nucleus since they condition the Rabl arrangement in G1 and chromosome partitioning during mitosis through their attachment to centromeres via the kinetochore proteins. Recently, we have shown that upon quiescence entry, intranuclear microtubules emanating from the spindle pole body elongate to form a highly stable bundle that spans the entire nucleus. Here, we examine some molecular mechanisms that may underlie the formation of this structure. As the intranuclear microtubule bundle causes a profound re-organization of the yeast nucleus and is required for cell survival during quiescence, we discuss the possibility that the assembly of such a structure participates in quiescence establishment.

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hal-01074775 , version 1 (15-10-2014)

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D Laporte, I Sagot. Microtubules move the nucleus to quiescence.. Nucleus, 2014, 5 (2), pp.113-8. ⟨10.4161/nucl.28538⟩. ⟨hal-01074775⟩

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