Nickel-Catalyzed Reductive Amination with Hydrosilanes.
Résumé
The authors have developed a nickel-catalyzed reductive amination of aldehydes using an in-situ-generated catalyst from nickel(II) acetate and tricyclohexylphosphine. The synthesis of the target compds. was achieved using tetramethyldisiloxane as a hydrosilane reagent. Secondary amines were formed in moderate-to-good product yields. The title compds. thus formed included 4-[[(4-methoxyphenyl)amino]methyl]phenol, N-(4-fluorophenyl)benzenemethanamine, N-[4-[[(4-methoxyphenyl)amino]methyl]phenyl]acetamide, N-(dodecyl)benzenemethanamine, N-(dodecyl)benzeneethanamine, N-octyl-1-dodecanamine, 4-[[(4-methoxyphenyl)amino]methyl]benzonitrile. [on SciFinder(R)]