Article Dans Une Revue Beilstein Journal of Organic Chemistry Année : 2014

Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation

Résumé

Readily accessible, low-valency glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by Pseudomonas aeruginosa. These multivalent ligands are simple to synthesize, are highly soluble, and can be either homofunctional or heterofunctional. The galactose-decorated cluster shows good affinity for Pseudomonas aeruginosa lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation.

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hal-01066711 , version 1 (22-09-2014)

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M. Smadhi, S. de Bentzmann, A. Imberty, M. Gingras, R. Abderrahim, et al.. Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation. Beilstein Journal of Organic Chemistry, 2014, 10, pp.1981-1990. ⟨10.3762/bjoc.10.206⟩. ⟨hal-01066711⟩
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