Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1
Résumé
The bioactive metabolite sphingosine-1-phosphate (S1P), a product of sphingosine kinases (SphKs), medi- ates diverse biological processes such as cell differentiation, proliferation, survival and angiogenesis. A fluorinated analogue of S1P receptor agonist has been synthesized by utilizing a ring opening reaction of oxacycles by a lithiated difluoromethylphosphonate anion as the key reaction. In vitro activity of this S1P analogue is also reported.