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Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2014

Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1

Résumé

The bioactive metabolite sphingosine-1-phosphate (S1P), a product of sphingosine kinases (SphKs), medi- ates diverse biological processes such as cell differentiation, proliferation, survival and angiogenesis. A fluorinated analogue of S1P receptor agonist has been synthesized by utilizing a ring opening reaction of oxacycles by a lithiated difluoromethylphosphonate anion as the key reaction. In vitro activity of this S1P analogue is also reported.

Domaines

Chimie organique
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Dates et versions

hal-01063240 , version 1 (11-09-2014)

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Citer

Lucie Aliouane, Sovy Chao, Brizuela Leyre, Emmanuel Pfund, Cuvillier Olivier, et al.. Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1. Bioorganic and Medicinal Chemistry, 2014, 22 (17), pp.4955-4960. ⟨10.1016/j.bmc.2014.06.038⟩. ⟨hal-01063240⟩
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