Railway operations management must cope with system failures and external disturbances that may cause delays. In heavy traffic areas, these delays can quickly propagate. This study details the results of a railway traffic optimization tool based on a MILP formulation. The case studies tackled represent different European locations. These experiments are part of a task the European FP7 project ON-TIME. The project aims to develop a prototype for a new generation of railway traffic management systems which will increase capacity and decrease delays for railway customers’ satisfaction.