In order to perform Prognostic and Health Management (PHM) of a given system, it is necessary to define some relevant variables sensitive to the different degradation modes of the system. Those variables are named Health Indicators (HI) and they are the keystone of PHM. However, they are subject to a lot of uncertainties when computed in real time and the stochastic nature of PHM makes it hard to evaluate the efficiency of a HI set before the extraction algorithm is implemented. This document introduces Numerical Key Performance Indicators (NKPI) for the validation of HI computed only from data provided by numerical models in the upstream stages of a PHM system development process. In order to match as good as possible the reality, the multiple sources of uncertainties are quantified and propagated into the model. After having introduced the issue of uncertain systems modeling, the different NKPI are defined and eventually an application is performed on a hydraulic actuation system of an aircraft engine.