The prediction of molecule's properties through Quantitative Structure Activity (resp. Property) Relationships are two active research fields named QSAR and QSPR. Within these frameworks Graph kernels allow to combine a natural encoding of a molecule by a graph with classical statistical tools such as SVM or kernel ridge regression. Unfortunately some molecules encoded by a same graph and differing only by the three dimensional orientations of their atoms in space have different properties. Such molecules are called stereoisomers. These latter properties can not be predicted by usual graph methods which do not encode stereoisomerism. In this paper we propose a new graph encoding of molecules taking explicitly into account stereoisomerism and propose a new kernel between these structures in order to predict properties related to stereoisomerism.