Citrus Flavanones: What Is Their Role in Cardiovascular Protection ? - Archive ouverte HAL
Article Dans Une Revue Journal of Agricultural and Food Chemistry Année : 2012

Citrus Flavanones: What Is Their Role in Cardiovascular Protection ?

Dragan Milenkovic
Claudine Manach
André Mazur
Christine Morand

Résumé

Flavanones, including hesperidin and naringin, are polyphenolic compounds highly and almost exclusively present in citrus. Epidemiological studies reported an inverse relationship between their intake and the risk of cardiovascular diseases. Clinical and experimental data further showed their antihypertensive, lipid-lowering, insulin-sensitizing, antioxidative, and anti-inflammatory properties, which could explain their antiatherogenic action in animal models. Although flavanones may be promising compounds that are particularly active in cardiovascular disease prevention, clinical data are still scarce and most in vitro data have been obtained under nonphysiologically relevant conditions. Moreover, the mechanisms responsible for flavanone action are not fully elucidated. Therefore, further research is needed to better evaluate and understand the protective effects of flavanones in cardiovascular diseases.
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Dates et versions

hal-01056770 , version 1 (20-08-2014)

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  • HAL Id : hal-01056770 , version 1

Citer

Audrey Chanet, Dragan Milenkovic, Claudine Manach, André Mazur, Christine Morand. Citrus Flavanones: What Is Their Role in Cardiovascular Protection ?. Journal of Agricultural and Food Chemistry, 2012, 60, pp.8809-8822. ⟨hal-01056770⟩
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