The intersection number of a graph G is the minimum size of a set S such that G is an intersection graph of some family of subsets F⊆2^S. The overlap number of G is defined similarly, except that G is required to be an overlap graph of F. Computing the overlap number of a graph has been stated as an open problem in [B. Rosgen and L. Stewart, 2010, arXiv:1008.2170v2] and [D.W. Cranston, et al., J. Graph Theory., 2011]. In this paper we show two algorithmic aspects concerning both these graph invariants. On the one hand, we show that the corresponding optimization problems associated with these numbers are both APX-hard, where for the intersection number our results hold even for biconnected graphs of maximum degree 7, strengthening the previously known hardness result. On the other hand, we show that the recognition problem for any specific intersection graph class (e.g. interval, unit disc, ...) is easy when restricted to graphs with fixed intersection number.