Optimization of intra-voxel incoherent motion imaging at 3.0 Tesla for fast liver examination.
B. Leporq
(1)
,
Hervé Saint-Jalmes
(2, 3)
,
C. Rabrait
(4)
,
F. Pilleul
(1, 5, 6)
,
O. Guillaud
(7)
,
J. Dumortier
(7)
,
J.-Y. Scoazec
(8)
,
O. Beuf
(1)
1
RMN et optique : De la mesure au biomarqueur
2 LTSI - Laboratoire Traitement du Signal et de l'Image
3 CRLCC - CRLCC Eugène Marquis
4 Clinical Science Development Group
5 Centre Léon Bérard [Lyon]
6 Departement d'imagerie Digestive
7 Département d'hépatologie
8 Département d'anatomopathologie, biopathologie
2 LTSI - Laboratoire Traitement du Signal et de l'Image
3 CRLCC - CRLCC Eugène Marquis
4 Clinical Science Development Group
5 Centre Léon Bérard [Lyon]
6 Departement d'imagerie Digestive
7 Département d'hépatologie
8 Département d'anatomopathologie, biopathologie
B. Leporq
- Fonction : Auteur
- PersonId : 169772
- IdHAL : benjamin-leporq
- ORCID : 0000-0002-3408-4156
- IdRef : 245140611
F. Pilleul
- Fonction : Auteur
- PersonId : 170728
- IdHAL : frank-pilleul
- ORCID : 0000-0002-9643-5230
- IdRef : 059516860
J. Dumortier
- Fonction : Auteur
- PersonId : 762386
- ORCID : 0000-0002-7824-5396
- IdRef : 07665933X
O. Beuf
- Fonction : Auteur
- PersonId : 19097
- IdHAL : olivier-beuf
- ORCID : 0000-0002-4516-4565
- IdRef : 112823564
Résumé
BACKGROUND: Optimization of multi b-values MR protocol for fast intra-voxel incoherent motion imaging of the liver at 3.0 Tesla. METHODS: A comparison of four different acquisition protocols were carried out based on estimated IVIM (DSlow , DFast , and f) and ADC-parameters in 25 healthy volunteers. The effects of respiratory gating compared with free breathing acquisition then diffusion gradient scheme (simultaneous or sequential) and finally use of weighted averaging for different b-values were assessed. An optimization study based on Cramer-Rao lower bound theory was then performed to minimize the number of b-values required for a suitable quantification. The duration-optimized protocol was evaluated on 12 patients with chronic liver diseases RESULTS: No significant differences of IVIM parameters were observed between the assessed protocols. Only four b-values (0, 12, 82, and 1310 s.mm(-2) ) were found mandatory to perform a suitable quantification of IVIM parameters. DSlow and DFast significantly decreased between nonadvanced and advanced fibrosis (P < 0.05 and P < 0.01) whereas perfusion fraction and ADC variations were not found to be significant. CONCLUSION: Results showed that IVIM could be performed in free breathing, with a weighted-averaging procedure, a simultaneous diffusion gradient scheme and only four optimized b-values (0, 10, 80, and 800) reducing scan duration by a factor of nine compared with a nonoptimized protocol. Preliminary results have shown that parameters such as DSlow and DFast based on optimized IVIM protocol can be relevant biomarkers to distinguish between nonadvanced and advanced fibrosis. J. Magn. Reson. Imaging 2014. © 2014 Wiley Periodicals, Inc.
Domaines
Traitement du signal et de l'image [eess.SP] Traitement du signal et de l'image [eess.SP] ImagerieFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
BACKGROUND: Optimization of multi b-values MR protocol for fast intra-voxel incoherent motion imaging of the liver at 3.0 Tesla. METHODS: A comparison of four different acquisition protocols were carried out based on estimated IVIM (DSlow , DFast , and f) and ADC-parameters in 25 healthy volunteers. The effects of respiratory gating compared with free breathing acquisition then diffusion gradient scheme (simultaneous or sequential) and finally use of weighted averaging for different b-values were assessed. An optimization study based on Cramer-Rao lower bound theory was then performed to minimize the number of b-values required for a suitable quantification. The duration-optimized protocol was evaluated on 12 patients with chronic liver diseases RESULTS: No significant differences of IVIM parameters were observed between the assessed protocols. Only four b-values (0, 12, 82, and 1310 s.mm(-2) ) were found mandatory to perform a suitable quantification of IVIM parameters. DSlow and DFast significantly decreased between nonadvanced and advanced fibrosis (P < 0.05 and P < 0.01) whereas perfusion fraction and ADC variations were not found to be significant. CONCLUSION: Results showed that IVIM could be performed in free breathing, with a weighted-averaging procedure, a simultaneous diffusion gradient scheme and only four optimized b-values (0, 10, 80, and 800) reducing scan duration by a factor of nine compared with a nonoptimized protocol. Preliminary results have shown that parameters such as DSlow and DFast based on optimized IVIM protocol can be relevant biomarkers to distinguish between nonadvanced and advanced fibrosis. J. Magn. Reson. Imaging 2014. © 2014 Wiley Periodicals, Inc.
|
Titre |
en
Optimization of intra-voxel incoherent motion imaging at 3.0 Tesla for fast liver examination.
|
Auteur(s) |
B. Leporq
1
, Hervé Saint-Jalmes
2, 3
, C. Rabrait
4
, F. Pilleul
1, 5, 6
, O. Guillaud
7
, J. Dumortier
7
, J.-Y. Scoazec
8
, O. Beuf
1
1
RMN et optique : De la mesure au biomarqueur
( 530749 )
- France
2
LTSI -
Laboratoire Traitement du Signal et de l'Image
( 182223 )
- Campus Universitaire de Beaulieu - Bât 22 - 35042 Rennes
- France
3
CRLCC -
CRLCC Eugène Marquis
( 301510 )
- Avenue Bataille Flandres-Dunkerque 35042 RENNES CEDEX
- France
4
Clinical Science Development Group
( 223469 )
- Buc
- France
5
Centre Léon Bérard [Lyon]
( 20549 )
- 28, rue Laennec 69373 LYON Cedex 08
- France
6
Departement d'imagerie Digestive
( 216517 )
- CHU Edouard Herriot, 69008 Lyon
- France
7
Département d'hépatologie
( 223421 )
- France
8
Département d'anatomopathologie, biopathologie
( 130411 )
- 69373 Lyon
- France
|
Date de publication |
2015
|
Date de publication électronique |
2014-07-11
|
Audience |
Internationale
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Nom de la revue |
|
Langue du document |
Anglais
|
Volume |
41
|
Numéro |
5
|
Page/Identifiant |
1209-1217
|
Domaine(s) |
|
Mots-clés |
en
MRI, IVIM, liver
|
DOI | 10.1002/jmri.24693 |
Pubmed Id | 25044653 |
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