Multiple ways of representing the emerging new genetic knowledge and its implications have resulted from recent research including the Human Genome Project. In this chapter, we discuss that the presentation of human genetics is now less deterministic, formulated in a more systemic approach, taking into account the interaction between the genes and their environment (epigenetics), discussing the notion of biological determinism, and including connections with ethical and social implications. How are these new genetic trends represented today in biology textbooks? Do multiple ways exist across cultures, languages, and countries? Two complementary sets of data are presented and discussed: (1) the representation of human genetic diseases in French biology textbooks, showing a frequent absence of a systemic approach with nevertheless some exceptions; and (2) a comparative analysis of biology textbooks in 16 countries, showing the common similarity in their use of an implicit message through the same clothes and hairstyle of identical twins, but strong differences--in their use of the metaphor genetic program--which depended on the sociocultural context of each country. We argue that the renewal of the taught representations of human genetics is not only correlated with the renewal of scientific knowledge, but also with implicit values underlying each country's sociocultural context.