The Hospital Centre of Tours (France) is reorganizing the logistic services between its hospital units. We focus on the vehicles routing problem (VRP) between these units and on the definition of a warehousemen team inside a particularly large hospital. The design of this team (composition, planning, ...) is strongly related to the routes of vehicles between hospital units. The whole problem can be seen as a two-level pickup and delivery problem with time windows, where two VRP interact