An adaptive mulitresolution method based on a second-order finite volume discretization is presented for solving the three-dimensional compressible Navier-Stokes equations in Cartesian geometry. The explicit time discretization is of second-order and for flux evaluation a 2-4 Mac Cormack scheme is used. Coherent Vortex Simulations (CVS) are performed by decomposing the flow variables into coherent and incoherent contributions. The coherent part is computed deterministically on a locally refined grid using the adaptive multiresolution method while the influence of the incoherent part is neglected to model turbulent dissipation. The computational efficiency of this approach in terms of memory and CPU time compression is illustrated for turbulent mixing layers in the weakly compressible regime and for Reynolds numbers based on the mixing layer thickness between 50 and 200. Comparisons with direct numerical simulations allow to assess the precision and efficiency of CVS.