Inactivation of the ybdD Gene in Lactococcus lactis Increases the Amounts of Exported Proteins - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Applied and Environmental Microbiology Année : 2012

Inactivation of the ybdD Gene in Lactococcus lactis Increases the Amounts of Exported Proteins

Résumé

Random insertional mutagenesis performed on a Lactococcus lactis reporter strain led us to identify L. lactis ybdD as a proteinoverproducing mutant. In different expression contexts, the ybdD mutant shows increased levels of exported proteins and therefore constitutes a new and attractive heterologous protein production host. This study also highlights the importance of unknownregulatory processes that play a role during protein secretion.

Dates et versions

hal-01019443 , version 1 (07-07-2014)

Identifiants

Citer

Eric E. Morello, Sébastien Nouaille, Naima G. Cortes-Perez, Sebastien Blugeon, Luis Fernando Medina, et al.. Inactivation of the ybdD Gene in Lactococcus lactis Increases the Amounts of Exported Proteins: Inactivation of the ybdD Gene in Lactococcus lactis Increases the Amounts of Exported Proteins. Applied and Environmental Microbiology, 2012, 78 (19), pp.7148-7151. ⟨10.1128/AEM.01076-12⟩. ⟨hal-01019443⟩
84 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More