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Article Dans Une Revue Dyes and Pigments Année : 2011

A versatile access to new halogenated 7-azidocoumarins for photoaffinity labeling: Synthesis and photophysical properties

Résumé

A versatile methodology for the synthesis of 6/8-halogenated 7-aminocoumarins from the corresponding 7-hydroxy analogs using Pd-catalyzed amination reaction as the key step is presented. Further readily conversion into 7-azidocoumarins was performed and the resulting aryl azides proved higher stability and reactivity than the corresponding non-halogenated parent compound. These new compounds may thus constitute attractive scaffolds for designing novel photoaffinity reagents for various challenging bio-labeling applications.

Domaines

Chimie organique

Dates et versions

hal-01017388 , version 1 (02-07-2014)

Identifiants

Citer

Emilia Paunescu, Ludivine Louise, Ludovic Jean, Anthony Romieu, Pierre-Yves Renard. A versatile access to new halogenated 7-azidocoumarins for photoaffinity labeling: Synthesis and photophysical properties. Dyes and Pigments, 2011, 91 (3), pp.427-434. ⟨10.1016/j.dyepig.2011.05.008⟩. ⟨hal-01017388⟩
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