<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01017140</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T17:37:47+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Quantification of cardiomyocyte contraction based on image correlation analysis.</title>
            <author role="aut">
              <persName>
                <forename type="first">Alain</forename>
                <surname>Kamgoué</surname>
              </persName>
              <email type="md5">59f9762f872a4a35ef57ad3a52b59bc8</email>
              <email type="domain">yahoo.fr</email>
              <idno type="idhal" notation="numeric">1412934</idno>
              <idno type="halauthorid" notation="string">723643-1412934</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0866-4154</idno>
              <affiliation ref="#struct-390591"/>
              <affiliation ref="#struct-591"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Ohayon</surname>
              </persName>
              <email type="md5">28ebfdc77ae6bc6745e6acd65ed048d2</email>
              <email type="domain">imag.fr</email>
              <idno type="idhal" notation="string">jacques-ohayon</idno>
              <idno type="idhal" notation="numeric">1322167</idno>
              <idno type="halauthorid" notation="string">147832-1322167</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6923-6850</idno>
              <idno type="IDREF">https://www.idref.fr/130341193</idno>
              <affiliation ref="#struct-707"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Y.</forename>
                <surname>Usson</surname>
              </persName>
              <email type="md5">4876e56c3620e53cc2bdc26b6684cbd5</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">yves-usson</idno>
              <idno type="idhal" notation="numeric">16660</idno>
              <idno type="halauthorid" notation="string">38256-16660</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/B-2002-2014</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0242-191X</idno>
              <idno type="IDREF">https://www.idref.fr/066890853</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/B-2002-2014</idno>
              <affiliation ref="#struct-388341"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Riou</surname>
              </persName>
              <idno type="halauthorid">186561-0</idno>
              <affiliation ref="#struct-27749"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Tracqui</surname>
              </persName>
              <idno type="halauthorid">147816-0</idno>
              <affiliation ref="#struct-390591"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Arnaud</forename>
                <surname>Chauvière</surname>
              </persName>
              <email type="md5">ef16547cfc184875e41da01f7fb1f848</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2014-07-01 19:27:50</date>
              <date type="whenModified">2026-01-19 12:26:15</date>
              <date type="whenReleased">2014-07-01 19:27:50</date>
              <date type="whenProduced">2009-04</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="181418">
                <persName>
                  <forename>Arnaud</forename>
                  <surname>Chauvière</surname>
                </persName>
                <email type="md5">ef16547cfc184875e41da01f7fb1f848</email>
                <email type="domain">univ-grenoble-alpes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01017140</idno>
            <idno type="halUri">https://hal.science/hal-01017140</idno>
            <idno type="halBibtex">kamgoue:hal-01017140</idno>
            <idno type="halRefHtml">&lt;i&gt;Cytometry Part A&lt;/i&gt;, 2009, 75 (4), pp.298-308. &lt;a target="_blank" href="https://dx.doi.org/10.1002/cyto.a.20700"&gt;&amp;#x27E8;10.1002/cyto.a.20700&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Cytometry Part A, 2009, 75 (4), pp.298-308. &amp;#x27E8;10.1002/cyto.a.20700&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-DYCTIM" corresp="TIMC-IMAG">DyCTim : Dynamique Cellulaire / Tissulaire et Microscopie fonctionnelle</idno>
            <idno type="stamp" n="TDS-MACS">Réseau de recherche en Théorie des Systèmes Distribués, Modélisation, Analyse et Contrôle des Systèmes</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="MCD">MCD</idno>
            <idno type="stamp" n="CBI">Centre de biologie intégrative</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Quantification of cardiomyocyte contraction based on image correlation analysis.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Alain</forename>
                    <surname>Kamgoué</surname>
                  </persName>
                  <email type="md5">59f9762f872a4a35ef57ad3a52b59bc8</email>
                  <email type="domain">yahoo.fr</email>
                  <idno type="idhal" notation="numeric">1412934</idno>
                  <idno type="halauthorid" notation="string">723643-1412934</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0866-4154</idno>
                  <affiliation ref="#struct-390591"/>
                  <affiliation ref="#struct-591"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Ohayon</surname>
                  </persName>
                  <email type="md5">28ebfdc77ae6bc6745e6acd65ed048d2</email>
                  <email type="domain">imag.fr</email>
                  <idno type="idhal" notation="string">jacques-ohayon</idno>
                  <idno type="idhal" notation="numeric">1322167</idno>
                  <idno type="halauthorid" notation="string">147832-1322167</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6923-6850</idno>
                  <idno type="IDREF">https://www.idref.fr/130341193</idno>
                  <affiliation ref="#struct-707"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Y.</forename>
                    <surname>Usson</surname>
                  </persName>
                  <email type="md5">4876e56c3620e53cc2bdc26b6684cbd5</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">yves-usson</idno>
                  <idno type="idhal" notation="numeric">16660</idno>
                  <idno type="halauthorid" notation="string">38256-16660</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/B-2002-2014</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0242-191X</idno>
                  <idno type="IDREF">https://www.idref.fr/066890853</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/B-2002-2014</idno>
                  <affiliation ref="#struct-388341"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Riou</surname>
                  </persName>
                  <idno type="halauthorid">186561-0</idno>
                  <affiliation ref="#struct-27749"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Tracqui</surname>
                  </persName>
                  <idno type="halauthorid">147816-0</idno>
                  <affiliation ref="#struct-390591"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">12354</idno>
                <idno type="issn">1552-4922</idno>
                <idno type="eissn">1552-4930</idno>
                <title level="j">Cytometry Part A</title>
                <imprint>
                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">75</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">298-308</biblScope>
                  <date type="datePub">2009-04</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1002/cyto.a.20700</idno>
              <idno type="pubmed">19107827</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Algorithms</classCode>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Myocytes, Cardiac</classCode>
              <classCode scheme="mesh">Rats</classCode>
              <classCode scheme="mesh">Sarcomeres</classCode>
              <classCode scheme="mesh">Software</classCode>
              <classCode scheme="mesh">Stress, Mechanical</classCode>
              <classCode scheme="mesh">Time Factors</classCode>
              <classCode scheme="mesh">Animals, Newborn</classCode>
              <classCode scheme="mesh">Cells, Cultured</classCode>
              <classCode scheme="mesh">Heart</classCode>
              <classCode scheme="mesh">Image Cytometry</classCode>
              <classCode scheme="mesh">Microscopy, Phase-Contrast</classCode>
              <classCode scheme="mesh">Microscopy, Video</classCode>
              <classCode scheme="mesh">Muscle Contraction</classCode>
              <classCode scheme="mesh">Myocardium</classCode>
              <classCode scheme="halDomain" n="info.info-mo">Computer Science [cs]/Modeling and Simulation</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Quantification of cardiomyocyte contraction is usually obtained by measuring globally cell shortening from the displacement of cell extremities. We developed a correlation-based optical flow method, which correlates the whole-cell temporal pattern with a precise quantification of the intracellular strain wave at the sarcomeres level. A two-dimensional image correlation analysis of cardiomyocytes phase-contrast images was developed to extract local cell deformations from videomicroscopy time-lapse sequences. Test images, synthesized from known intensity displacement fields, were first used to validate the method. Intracellular strain fields were then computed from videomicroscopy time-lapse sequences of single adult and neonatal cardiomyocytes. The propagation of the sarcomeres contraction-relaxation wave during cell contraction has been successfully quantified. The time-varying patterns of intracellular displacement were obtained accurately, even when cardiomyocyte bending occurred in pace with contraction. Interestingly, the characterization of the successive 2D displacement fields show a direct quantification of the variation with time of intracellular strains anywhere in the cell. The proposed method enables a quantitative analysis of cardiomyocyte contraction without requiring wave tracking with the use of fluorescent calcium probes. Thus, our algorithmic approach provides a fast and efficient tool for analyzing the correlation between global cell dynamical behavior and mechanosensitive intracellular processes.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-390591" status="INCOMING">
          <orgName>DynaCell</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-591" status="OLD">
          <idno type="IdRef">240562674</idno>
          <idno type="RNSR">199911785U</idno>
          <orgName>Laboratoire de biologie moléculaire eucaryote</orgName>
          <orgName type="acronym">LBME</orgName>
          <date type="start">1999-01-01</date>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>Bât IBCG 118 Route de Narbonne 31062 TOULOUSE CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www-ibcg.biotoul.fr/recherche.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="UMR5099" active="#struct-441569" type="direct"/>
            <relation active="#struct-552481" type="direct"/>
            <relation name="FR3743" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-388341" status="INCOMING">
          <orgName>RFMQ</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-27749" status="OLD">
          <orgName>Radiopharmaceutiques biocliniques</orgName>
          <desc>
            <address>
              <addrLine>Faculté de médecine et de pharmacie domaine de la merci Bâtiment Jean Roget 38700 LA TRONCHE</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation name="U877" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-552481" status="OLD">
          <idno type="RNSR">201622188C</idno>
          <orgName>Centre de Biologie Intégrative</orgName>
          <orgName type="acronym">CBI</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Université Paul Sabatier,18 Route de Narbonne, 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cbi-toulouse.fr/fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="FR3743" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>