Article Dans Une Revue ACS Medicinal Chemistry Letters Année : 2013

Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole

Résumé

Synthesis of a strict structural analogue of albaconazole in which the quinazolinone ring is fused by a thiazole moiety led to the discovery of a new triazole with broad-spectrum antifungal activity. Compound I exhibited high in vitro activity against pathogenic Candida species and filamentous fungi and showed preliminary in vivo antifungal efficacy in a mice model of systemic candidiasis.

Dates et versions

hal-01015468 , version 1 (26-06-2014)

Identifiants

Citer

Rémi Guillon, Fabrice Pagniez, Carine Picot, Damien Hédou, Alain Tonnerre, et al.. Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole. ACS Medicinal Chemistry Letters, 2013, 4 (2), pp.288-292. ⟨10.1021/ml300429p⟩. ⟨hal-01015468⟩
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