This chapter presents different numerical modeling strategies for the evaluation of seismic vulnerability of an existing structure (a building located in the Grenoble area, France) using multi‐fiber beams and constitutive laws based on the damage mechanics and plasticity. The dynamic behavior of the structure shows two structural sensitive zones: at the base, and at the bottom of the standard stories. The comparison between the pushover (based on the first bending mode) and the dynamic analysis shows very close maximal deformed shapes of the structure. The use of the same damage indicators as those used for the dynamic analysis enables a comparison of their accuracy. In addition, the analysis on the multi‐fiber model enables us to exploit the EMS‐98 damage levels for which its description is related to local variables. The multi‐fiber beam strategy allows us to fully exploit the definitions of the damage level based on structural criteria.