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Communication Dans Un Congrès Année : 2013

Epigenetic of gametes and fertility in male: potential consequences on progeny

Résumé

A global increase of the male infertlity is described for different species. Human infertility affects 10-15% of couples and among infertlity causes, one third has a male origin (Louis, 2013). The genetic causes of male infertility have been searched (ka1yotypic abnonnalities, microdeletions, mutations ; Maduro, 2003). ln cattle, the importance of male contribution to reproductive success is weil documented, bull breeding soundness evaluation are a commercial practice and there are specifie guidelines for semen evaluation. Hovewer, a surprisingly law number of quantitative trait loci (QTLs), genome-wide association studies (GWAS) and genomic selection (GS) approaches have reported candidate genes associated with fertility tmits (Fortes 2313). ln recent years, it become inc1*easingly ciear that epigenetic mechanisms are critical during spennatogenesis and that perturbations in these mechanisms can result in male sublinfeltility (Zamudio, 2008; CaiTell, 2012; Chalas­ Boissonnas, 2013). The current knowledge on epigenetic that occur during male meiosis is discussed in this review. A special attenton is focused on DNA methylation, histone tail modifications, targeted histone reteltion and protamine incorporation into the chromatin, and small and long non coding RNA production. Ali these epigenetic mechanims are involved in highly regulated processes such as silencing of gene and retrotransposon, chromatin condensation and packaging of DNA. We will discuss the importance of a better understanding of how epigenetic changes in the spenn may have a causative role in etiology of infertility. Perturbations in the establisment and lor maintenance of any of these epigenetic marks could be induced by environmental factors and could affect the fertility status. These epigenetic marks constitute also the paternal contribution to embryo development. Finally, the recent studies focused on t*ansgenerational and paternal effects in mice and in human are discussed.

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Dates et versions

hal-01004780 , version 1 (11-06-2014)

Identifiants

  • HAL Id : hal-01004780 , version 1
  • PRODINRA : 226426

Citer

Hélène Jammes, Hélène Kiefer, Evelyne E. Campion. Epigenetic of gametes and fertility in male: potential consequences on progeny. Epigenetics and Periconception Environment, European Cooperation in Science and Technology (COST). BEL., Oct 2013, Sant Feliu de Guixols, Spain. pp.26. ⟨hal-01004780⟩
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