Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents. - Archive ouverte HAL
Article Dans Une Revue Archiv der Pharmazie / Chemistry in Life Sciences Année : 2014

Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents.

Résumé

Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2/KI/K10) was used as catalyst in the cycloaddition of azides and propargylnucleobases, to provide the corresponding 1,4-disubstituted 1,2,3-triazoles in good yield. All compounds 16-23 were evaluated for their antiviral activity in vitro. Compound 18 showed moderate inhibition against influenza virus A (H3N2).

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Chimie organique

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https://hal.science/hal-01004380

Soumis le : mercredi 11 juin 2014-11:46:10

Dernière modification le : mercredi 4 décembre 2024-10:20:03

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Dates et versions

hal-01004380 , version 1 (11-06-2014)

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Hanane Elayadi, Michael Smietana, Jean-Jacques Vasseur, Jan Balzarini, Hassan B. Lazrek. Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents.. Archiv der Pharmazie / Chemistry in Life Sciences, 2014, 347 (2), pp.134-141. ⟨10.1002/ardp.201300260⟩. ⟨hal-01004380⟩

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