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Article Dans Une Revue Animal Genetics Année : 2011

Expression levels of 25 genes in liver and testis located in a QTL region for androstenone on SSC7q1.2

Annie Robic
Katia K. Feve
Yvon Billon
M. M. van Son
  • Fonction : Auteur
Laurence Liaubet
Denis Milan
E. E. Grindflek
  • Fonction : Auteur
Juliette Riquet

Résumé

A quantitative trait locus (QTL) for boar fat androstenone levels has been identified near the SSC7 centromere in a Large White × Meishan cross. Backcrosses were produced to isolate the Chinese haplotype in a European genetic background. The expression of 25 genes from the QTL region was studied in the testes and livers of 5-month-old backcross boars, with the aim of identifying the causal gene. Using Fluidigm, a new high-throughput technology, the expression of 25 genes was measured in a single real-time PCR experiment. This study found six significantly down-regulated genes (C6ORF106, C6ORF81, CLPS, SLC26A8, SRPK1 and MAPK14) in the testes of MS-LW backcross boars. However, according to current knowledge, none of the genes appear to be related to androstenone metabolism. In the livers, none of the genes were significantly up- or down-regulated, including TEAD3, which was previously designated as a possible candidate to explain this QTL.

Dates et versions

hal-01001156 , version 1 (04-06-2014)

Identifiants

Citer

Annie Robic, Katia K. Feve, Catherine Larzul, Yvon Billon, M. M. van Son, et al.. Expression levels of 25 genes in liver and testis located in a QTL region for androstenone on SSC7q1.2. Animal Genetics, 2011, 42 (6), pp.662-665. ⟨10.1111/j.1365-2052.2011.02195.x⟩. ⟨hal-01001156⟩
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