Immunotherapy of allergic diseases using probiotics or recombinant probiotics
Résumé
Allergic diseases affect up to 30% of the western population, and their prevalence is increasing. Probiotics are able to modulate the mucosal immune response, and clinical trials demonstrated that specific strains, especially lactic acid bacteria (LAB) ones, reduce allergic symptoms. Moreover, the use of recombinant probiotics has been evaluated as possible strategies for the immunotherapy of allergic diseases. The production and delivery of allergens by recombinant Lin concert with their ability to induce a Th1-type immune response have been shown to be a promising mucosal vaccination strategy in mouse model. The aim of this article is to review the applications of probiotics in allergy immunotherapy with a special focus on recombinant Ldelivering proteins or DNA.
Mots clés
allergic diseases
allergy treatment
immunotherapy
lactic acid bacteria
recombinant probiotics
-lactoglobulin
BOVINE BETA-LACTOGLOBULIN
LACTIC-ACBACTERIA
MILK PROTEIN ALLERGY
MAMMALIAN EPITHELIAL-CELLS
LACTOCOCCUS-LACTIS
DENDRITIC CELLS
LACTOBACILLUS-PLANTARUM
GENETIC IMMUNIZATION
IMMUNE-RESPONSE
AIRWAY INFLAMMATION