Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Organic Chemistry Année : 2013

Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality.

Résumé

Highly atroposelective Meyers' lactamization promoted by pivalic acid under microwave irradiation is reported which allows the construction of nonracemic substituted-dibenzo(di)azepine derivatives through a center to axial chirality transfer principle, controlling the otherwise configurationally labile biaryl axis. This approach provides a straightforward entry to enantioenriched analogues of biorelevant architectures.

Domaines

Chimie organique
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Dates et versions

hal-00997427 , version 1 (28-05-2014)

Identifiants

Citer

Svetlana Postikova, Mohamad Sabbah, Daniel Wightman, Ich Tuan Nguyen, Morgane Sanselme, et al.. Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality.. Journal of Organic Chemistry, 2013, 78 (16), pp.8191-8197. ⟨10.1021/jo401259w⟩. ⟨hal-00997427⟩
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