Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Organic Chemistry Année : 2013

Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics.

Résumé

A straightforward, easy, and practical access to various amino acid analogues (methionine, leucine, lysine, and arginine) from a unique fluorinated cyclopropane scaffold is described. Moreover, the synthesis, for the first time, of one tripeptide incorporating a fluorinated cyclopropane amino acid (FCAA) analogue is reported.

Domaines

Chimie organique
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Dates et versions

hal-00996635 , version 1 (26-05-2014)

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Citer

Gaëlle Milanole, Samuel Couve-Bonnaire, Jean-François Bonfanti, Philippe Jubault, Xavier Pannecoucke. Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics.. Journal of Organic Chemistry, 2013, 78 (2), pp.212-223. ⟨10.1021/jo302222n⟩. ⟨hal-00996635⟩
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